Mucosal Immunology Group Publications (2002 - 2007)

  1. Knight, P.A., Brown, J.K., and Pemberton, A.D.  Innate immune response mechanisms in the intestinal epithelium; potential roles for mast cells and goblet cells in the expulsion of Trichinella spiralis adult worms.  (Parasitology,in press).
  2. Knight, P.A.,  Brown, J.K.,  Wright, S.H., Thornton, E.M.,  Pate, J.A. and  Miller, H.R.P.  Aberrant mucosal mast cell protease expression in the enteric epithelium of nematode-infected mice lacking integrin avb6, a TGF-b1 activator.  (Am J. Pathology, in press).
  3. Knight, P.A., Pate, J.,  Smith, W.D.  and Miller, H.R.P.   An ovine chitinase-like molecule, Chitinase-3 like-1 (YKL-40), is upregulated in the abomasum in response to challenge with the gastrointestinal nematode, Teladorsagia circumcincta.  Veterinary Immunology and Immunopathology (In Press).
  4. French, A.T., Bethune, J.A.,  Knight, P.A.,  McNeilly,  T., Miller, H.R.P., Pemberton, A.D.  The expression  of intelectin in sheep goblet cells and upregulation by IL4.  Veterinary Immunology and Immunopathology (In press).
  5. N.M. Craig, W.D. Smith, H.R.P. Miller, W.I. Morrison and P.A. Knight.  Ovine cytokine expression in response to infection with Teladorsagia circumcincta. Veterinary Immunology and Immunopathology (In Press).
  6. Dacre, K. J., McAleese S. M., Knight P.A. , McGorum B. C. and Pemberton, A.D.  cDNA cloning and substrate specificity of equine tryptase, a possible mediator in equine heaves.  Clinical and Experimental Allergy  36: 1303-130
  7. Miller, H.R.P, Knight, P.A., and Pemberton, A.D.  2006.  Mucus; modulation by the TH2 response to enhance an innate defensive barrier against gut nematodes.  Parasite Immunology 28:259-262
  8. Pemberton,A.D., S.H.Wright, P.A.Knight, and H.R.P. Miller. 2006. Anaphylactic release of mucosal mast cell granule proteases: role of serpins in the differential clearance of mouse mast cell proteases-1 and -2. Journal of  Immunology. 176:899-904
  9. Pemberton,A.D., J.K.Brown, S.H.Wright, P.A.Knight, and H.R.Miller. 2006. The proteome of mouse mucosal mast cell homologues: The role of transforming growth factor beta(1). Proteomics, 6; 623-631
  10. McAleese,S.M., J.K.Brown, A.I.Macrae, A.Mackellar, J.F.Huntley, and H.R.Miller. 2006. Cloning and expression of the extra-cellular part of the alpha chain of the equine high-affinity IgE receptor and its use in the detection of IgE. Vet. Immunol. Immunopathol. 110:187-191.
  11. Brown,J.K., S.M.McAleese, E.M.Thornton, J.A.Pate, A.Schock, A.I.Macrae, P.R.Scott, H.R.Miller, and D.D.Collie. 2006. Integrin-alphavbeta6, a putative receptor for foot-and-mouth disease virus, is constitutively expressed in ruminant airways. J. Histochem. Cytochem. 54:807-816
  12. Owyang,A.M., C.Zaph, E.H.Wilson, K.J.Guild, T.McClanahan, H.R.Miller, D.J.Cua, M.Goldschmidt, C.A.Hunter, R.A.Kastelein, and D.Artis. 2006. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J. Exp. Med. 203:843-849.
  13. Shin,K., M.F.Gurish, D.S.Friend, A.D.Pemberton, E.M.Thornton, H.R.Miller, and D.M.Lee. 2006. Lymphocyte-independent connective tissue mast cells populate murine synovium. Arthritis Rheum. 54:2863-2871.
  14. Abonia, J.P., D.S. Friend, W.G. Austen, F.D. Moore, M.C. Carroll, R. Chan, J. Afnan, A. Humbles, C. Gerard, P.A. Knight, Y. Kanaoka, S. Yasuda, N. Morokawa, K.F. Austen, R.L. Stevens and M. F. Gurish.  2005.  Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. Journal of Immunology, 174:  7285-7291
  15. Wang, M. L., M. E.Shin, P. A. Knight, D.Artis, D. G. Silberg, E. Suh and G. D.Wu.  2005.  Regulation of RELM/FIZZ isoform expression by Cdx2 in response to innate and adaptive immune stimulation in the intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology. 288; G1074-G1083
  16. Weller,C.L., S.J.Collington, J.K.Brown, H.R.Miller, A.Al-Kashi, P.Clark, P.J.Jose, A.Hartnell, and T.J.Williams. 2005. Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. J. Exp. Med. 201:1961-1971.
  17. McAleese,S.M., J.K.Brown, A.I.Macrae, A.Mackellar, J.F.Huntley, and H.R.Miller. 2005. Cloning and expression of the extra-cellular part of the alpha chain of the equine high-affinity IgE receptor and its use in the detection of IgE. Vet. Immunol. Immunopathol.
  18. Zamolodchikova,T.S., E.V.Smirnova, A.N.Andrianov, I.V.Kashparov, O.D.Kotsareva, E.A.Sokolova, K.B.Ignatov, and A.D.Pemberton. 2005. Cloning and molecular modeling of duodenase with respect to evolution of substrate specificity within mammalian serine proteases that have lost a conserved active-site disulfide bond. Biochemistry (Mosc. ) 70:672-684.
  19. Van den Broek,A.H., J.F.Huntley, A.Mackellar, J.Machell, M.A.Taylor, and H.R.Miller. 2005. Characterisation of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep with Psoroptes ovis, the sheep scab mite. Vet. Immunol. Immunopathol. 105:141-150.
  20. Knight, P.A., A. D. Pemberton, K. A. Robertson, D. J. Roy, S. H. Wright and H.R.P. Miller. 2004.  Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis.  Infection and Immunity.  72: 6076-6086
  21. Artis, D., M.L. Wang, S. Keilbaugh, W. He, M. Brunes, G.P. Swain, P. A. Knight, D.D. Donaldson, H.R.P Miller, G.A. Schad, P. Scott, and G.D. Wu.  2004. RELMb/FIZZ2 is a novel goblet cell-specific immune effector molecule in the gastrointestinal tract.  PNAS 101:  13596-13600
  22. Pemberton, A.D., P.A. Knight, J. Gamble, M. Pierce, H. R.P. Miller. 2004. The novel lectin, intelectin-2 is highly upregulated in the jejunum during Trichinella spiralis infection of resistant BALB/c mice, but is not expressed by susceptible C57BL/10 mice. Journal of Immunology 173: 1894-1901
  23. Brown, J.K.,  P.A. Knight, A. D. Pemberton, S. H. Wright, J A Pate, E. M. Thornton and H.R.P. Miller.  2004  Expression of integrin-aE by mucosal mast cells in the intestinal epithelium and its absence in nematode infected mice lacking the TGF-b1 activating integrin avb6.  American Journal of Pathology 165: 95-106
  24. Lawrence, C.E., Y.Y.W Paterson, S.H. Wright, P.A. Knight, and H.R.P Miller. 2004. Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helmith infection in the mouse. Gastroenterology 127:155-165
  25. Pemberton, A.D., P.A. Knight, S.H. Wright and H.R.P. Miller. 2004  Proteomic analysis of mouse jejunal epithelium and its response to infection with the intestinal nematode, Trichinella spiralis. Proteomics 4: 1101-1108
  26. van den Broek,A.H., R.W.Else, J.F.Huntley, J.Machell, M.A.Taylor, and H.R.Miller. 2004. Early innate and longer-term adaptive cutaneous immunoinflammatory responses during primary infestation with the sheep scab mite, Psoroptes ovis. J. Comp Pathol. 131:318-329.

  27. Artis,D., A.Villarino, M.Silverman, W.He, E.M.Thornton, S.Mu, S.Summer, T.M.Covey, E.Huang, H.Yoshida, G.Koretzky, M.Goldschmidt, G.D.Wu, S.F.de, H.R.Miller, C.J.Saris, P.Scott, and C.A.Hunter. 2004. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J. Immunol. 173:5626-5634.

  28. Brown,J.K., A.D.Pemberton, S.H.Wright, and H.R.Miller. 2004. Primary antibody-Fab fragment complexes: a flexible alternative to traditional direct and indirect immunolabeling techniques. J. Histochem. Cytochem. 52:1219-1230.
    29.  
  29. De,J.F., A.De Laet, N.L.Van, J.K.Brown, H.R.Miller, P.P.van Bogaert, J.P.Timmermans, and A.B.Kroese. 2004. In vitro activation of murine DRG neurons by CGRP-mediated mucosal mast cell degranulation. Am. J. Physiol Gastrointest. Liver Physiol 287:G178-G191.
  30. Gurish,M.F., P.J.Bryce, H.Tao, A.B.Kisselgof, E.M.Thornton, H.R.Miller, D.S.Friend, and H.C.Oettgen. 2004. IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J. Immunol. 172:1139-1145.
  31. Garcia-Sanchez,A., R.Cerrato, J.Larrasa, N.C.Ambrose, A.Parra, J.M.Alonso, M.Hermoso-de-Mendoza, J.M.Rey, M.O.Mine, P.R.Carnegie, T.M.Ellis, A.M.Masters, A.D.Pemberton, and J.Hermoso-de-Mendoza. 2004. Characterisation of an extracellular serine protease gene (nasp gene) from Dermatophilus congolensis. FEMS Microbiol. Lett. 231:53-57.
  32. Brown, J. K., P. A. Knight, S. H. Wright, E. M. Thornton, and H. R. Miller 2003. Constitutive secretion of the granule chymase mouse mast cell protease-1 and the chemokine, CCL2, by mucosal mast cell homologues. Clinical and Experimental Allergy. 33:132-46.
  33. Pemberton, A. D., J. K. Brown, S. H. Wright, P. A. Knight, M. L. McPhee, A. R. McEuen, P. A. Forse, and H. R. Miller 2003. Purification and characterization of mouse mast cell proteinase-2 and the differential expression and release of mouse mast cell proteinase-1 and -2 in vivo. Clinical and Experimental Allergy. 33:1005-12.
  34. McDermott,J.R., R.E.Bartram, P.A.Knight, H.R.Miller, D.R.Garrod, and R.K.Grencis. 2003. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc. Natl. Acad. Sci. U. S. A 100:7761-7766.

  35. De,J.F., N.L.Van, D.Adriaensen, M.F.Van, H.R.Miller, M.E.Van, and J.P.Timmermans. 2003. Effect of intestinal inflammation on capsaicin-sensitive afferents in the ileum of Schistosoma mansoni-infected mice. Histochem. Cell Biol. 119:477-484.
  36. Miller,H.R., T.L.Randolph, and F.B.Peairs. 2003. Categories of resistance at four growth stages in three wheats resistant to the Russian wheat aphid (Homoptera: Aphididae). J. Econ. Entomol. 96:673-679.

  37. McDermott,J.R., R.E.Bartram, P.A.Knight, H.R.Miller, D.R.Garrod, and R.K.Grencis. 2003. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc. Natl. Acad. Sci. U. S. A 100:7761-7766.

  38. Brown,J.K., D.S.Donaldson, S.H.Wright, and H.R.Miller. 2003. Mucosal mast cells and nematode infection: strain-specific differences in mast cell precursor frequency revisited. J. Helminthol. 77:155-161.
  39. McAleese,S.M. and H.R.Miller. 2003. Cloning and sequencing of the equine and ovine high-affinity IgE receptor beta-and gamma-chain cDNA. Immunogenetics 55:122-125.

  40. van den Broek,A.H., J.F.Huntley, R.E.Halliwell, J.Machell, M.Taylor, and H.R.Miller. 2003. Cutaneous hypersensitivity reactions to Psoroptes ovis and Der p 1 in sheep previously infested with P. ovis--the sheep scab mite. Vet. Immunol. Immunopathol. 91:105-117.

  41. van den Broek,A.H., J.F.Huntley, J.Machell, M.A.Taylor, and H.R.Miller. 2003. Temporal pattern of isotype-specific antibody responses in primary and challenge infestations of sheep with Psoroptes ovis--the sheep scab mite. Vet. Parasitol. 111:217-230.
  42. Knight, P. A., S. H. Wright, J. K. Brown, X. Huang, D. Sheppard, and H. R. Miller 2002. Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. American Journal of Pathology. 161:771-9.
  43. Wright, S. H., J. Brown, P. A. Knight, E. M. Thornton, P. J. Kilshaw, and H. R. Miller 2002. Transforming growth factor-beta1 mediates coexpression of the integrin subunit alphaE and the chymase mouse mast cell protease-1 during the early differentiation of bone marrow-derived mucosal mast cell homologues. Clinical and Experimental Allergy. 32:315-24
  44. Rosbottom, A., P.A.Knight, G. McLachlan, E.M. Thornton, S.H. Wright, H. R. P. Miller and C.L. Scudamore. 2002.  Chemokine and cytokine expression in murine intestinal epithelium following Nippostrongylus brasiliensis infection.  Parasite Immunology 24: 67-75
  45. Nuttall, T. J., P. A. Knight, S. M. McAleese, J. R. Lamb, and P. B. Hill 2002. Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. Clinical and Experimental Allergy. 32:789-95.
  46. Rosbottom,A., C.L.Scudamore, M.H.von der, E.M.Thornton, S.H.Wright, and H.R.Miller. 2002. TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7. J. Immunol. 169:5689-5695.

  47. Lee,A.J., J.Machell, A.H.van den Broek, A.J.Nisbet, H.R.Miller, R.E.Isaac, and J.F.Huntley. 2002. Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens. Parasite Immunol. 24:413-422.

  48. De,J.F., N.L.Van, M.F.Van, H.R.Miller, M.E.Van, and J.P.Timmermans. 2002. Temporal distribution of distinct mast cell phenotypes during intestinal schistosomiasis in mice. Parasite Immunol. 24:225-231.

  49. Ridyard,A.E., T.J.Nuttall, R.W.Else, J.W.Simpson, and H.R.Miller. 2002. Evaluation of Th1, Th2 and immunosuppressive cytokine mRNA expression within the colonic mucosa of dogs with idiopathic lymphocytic-plasmacytic colitis. Vet. Immunol. Immunopathol. 86:205-214.

  50. Miller,H.R. and A.D.Pemberton. 2002. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology 105:375-390.

  51. Pemberton,A.D., T.S.Zamolodchikova, C.L.Scudamore, E.R.Chilvers, H.R.Miller, and T.R.Walker. 2002. Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts. Eur. J. Biochem. 269:1171-1180.
  52. Chen,T.A., R.E.Halliwell, A.D.Pemberton, and P.B.Hill. 2002. Identification of major allergens of Malassezia pachydermatis in dogs with atopic dermatitis and Malassezia overgrowth. Vet. Dermatol. 13:141-150.
  53. Nuttall,T.J., P.A.Knight, S.M.McAleese, J.R.Lamb, and P.B.Hill. 2002. T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis. Vet. Immunol. Immunopathol. 87:379-384.
  54. Nuttall,T.J., A.D.Pemberton, J.R.Lamb, and P.B.Hill. 2002. Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis. Vet. Immunol. Immunopathol. 84:143-150.