The Miller GroupThe Miller group has a strong track record in studying mucosal immunity in nematode parasitism and allergic inflammation in general. Such allergic reactions are typified by mast cell and eosinophil recruitment, increased numbers of goblet cells and enhanced mucus release. Our primary research interest is in mast cells, their recruitment to the epithelium and how mucosal mast cell specific proteases, which are produced in abundance by rodents, function within the affected mucosa. A key role for the proteases may be in regulating epithelial tight junctions, thus controlling epithelial permeability |
![[ The Miller and Morrison Research Group ]](/vtri/system/images/group_miller_morrison_s.jpg "[ The Miller and Morrison Research Group ]") Joint photo of Hugh Miller and Ivan Morrison’s groups outside the Hospital for Small Animals, Easter Bush |
Further to this, we are employing current methods for global analysis of gene transcription (micro-arrays) and protein expression (proteomics) to discover novel molecules and patterns of expression in allergic reactions and parasite rejection. A group of candidate molecules, including intelectin, resistin-like molecule beta and acidic mammalian chitinase are being studied in more detail. In particular, determining the involvement of these molecules in gastrointestinal parasitism of sheep is a major goal. By understanding how natural immunity to parasites works, we will be in a better position to augment these processes and design effective vaccines. PublicationsView the Miller Group Publications. |
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